Neurological Disorders

beginning with the letter...

Wernicke-Korsakoff syndrome is caused by thiamine deficiency, often associated with alcoholism.  The thiamine deficiency leads to necrosis of the mammillary bodies and changes in the medial diencephalic and periventricular regions.

Common symptoms include eye movement abnormalities, ataxia and confusion.  Neuropsychological testing typically reveals impaired sequencing ability, judgment, impulse control and initiative.  Disinhibition and limited self-insight often lead to confabulation in these patients.